CA 125 is a protein in the blood that goes up when a woman has ovarian cancer. The trouble is, this protein also goes up when a woman has other health problems that do not involve cancer. The test can help find ovarian cancer, but it is not very accurate!
CA 125 levels are elevated in approximately 1 percent of healthy women and fluctuate during the menstrual cycle. CA 125 is also increased in a variety of benign and malignant conditions, including:
?Uterine leiomyoma (Fibroids)
?Cirrhosis with or without ascites
?Pelvic inflammatory disease
?Cancers of the endometrium, breast, lung, and pancreas
?Pleural or peritoneal fluid due to any cause
Unfortunately, the CA 125 is a screening marker, and is limited in many situations.
It sounds as though your GP wants to trend the CA125 level.
Having said that, you must also correlate your risk factors for ovarian cancer.
Strong risk factors include
1. Familial ovarian cancer syndrome (rare) (lifetime probability % 30 to 50)
2. Two or three relatives with ovarian cancer (life time probability 5.5% (15 if first degree)
3. One relative (first or second degree) with ovarian cancer (life time probabilty 3.7% (5 if first degree)
There are other risk factors, but these are a few major ones.
Summary - DONT PANIC! Your elevated CA125 could be elevated for many other benign conditions such as your fibroids you mentioned.
Follow up with your GP as scheduled and feel free to address any concerns or anxiety with him/her about any lab results.
Hope this helped....Take care!