What does the following results mean: The specimen consists predominantly of squames. The background contains crystals and occasional histiocytes. There is a single grouping of degenerated urothelial cells present. These groupings contain cells with increased N:C ratios with hyperchromatic chromatin. positive degenerated urothelial cells present raises possibility of low-grade lesion. I had a renal ultrasound done - normal I had a cystoscopy done - normal
ANSWER: Hello Gwen:
The report details microscopic examination of urine. Crystals are found along with histiocytes which are scavenger cells in the urine. these findings are not clinically significant.
However, there is seen a group of cells "degenerated urothelial cells" These cells are having an enlarged nucleus in proportion to the cytoplasm of cells. This is considered suspicious....maybe a low grade cancer cell or a cell which has undergone change having been in the urine for a while.
If cystoscopy is normal, this could a degenerated cell group(basically dying cells) Your physician may ask for a repeat urine exam just to rule out presence of such abnormal cells. If these are not found in the repeat sample, there is no cause for worry
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Is having cells with hyperchromatic chromatin significant in understanding the results of the urine cytology test?